For extreme diseases, extreme methods of cure, as to restriction, are most suitable.1:6; Variant translations: Extreme remedies are very appropriate for extreme diseases. Compare: A desperate disease requires a dangerous remedy, Guy Fawkes, in admitting to the Gunpowder Plot; Diseases desperate grown / By desperate appliance are relieved, / Or not at all, William Shakespeare, Hamlet, Act iv, Scene 3; For a desperate disease a desperate cure, Michel de Montaigne, The Custom of the Isle of Cea, Chapter iii.